Azelaic acid. 
Azelaic acid is an organic chemical compound with the formula HOOC(CH2)7COOH. Azelaic acid is acid, which is of an organic nature hydrocarbon skeleton construction. Saturated acid tin participate in commutation reactions, because of the uncomplicated bond may likewise hold upwards called a obese acid. It contains two carboxyl groups to decide its acidic character. The carboxyl groups are located at both ends of the carbon-hydrogen chain that supports the polymerization, past times way dehydrating the reaction of 2 dissimilar monomers (heteropolymers synthesis).
Formula: C9H16O4
Melting point: 109°C
Density: 1.443 g/mL
Molar mass: 188.22 g/mol
Its dissociation takes house inwards 2 stages, past times showtime forming a monocyclic anion. Then shape a second carboxylic anion. Dissociation is carried out inwards 2 stages though in that location are 2 exponents of reporting. Are possible intermolecular bonds of hydrogen type, which growth the solubility and the boiling indicate of the compound. The chemical compound is water-soluble.
Azelaic acid has the same chemic properties equally all other carboxylic acids. The acid reacts with metals, metallic oxides, metallic hydroxides, salts, alcohols of obese alcohols of the aromatic type, phosphorus trichloride, phosphorus pentachloride. The acid likewise participates inwards the decomposition processes decarboxylation equally good equally inwards combustion processes.
Uses Of Azelaic Acid.
The usage of azelaic acid is mainly inwards cosmetic agents inwards combination with excipients. Usually
to the application of creams tin exclusively possess got a local impact. As the top dog activity is anti-microbial, anti-inflammatory in addition to introduces carbonization, equally the recovery procedure of the peel to eliminate clogging the pores in addition to acne appearance of the ordinary type.
It is of import earlier using the drug to mandatory consultation with the doc because of the drug combined with retinoids may possess got depigmentation manifestation.
Medicinal products containing azelaic acid pharmaceutical marketplace are:
- Skinoren cream of xxx grams to 20% content of azelaic acid;
- Finatseya gel of xxx grams of a 15% content of azelaic acid;
- Bielenda exfoliant gel of l grams with a content of 5% azelaic acid;
Before use, the formulation must possess got a cheque for allergenicity in addition to hypersensitivity. Blend on the formulation should hold upwards exclusively on areas that need. Azelaic acid should non autumn on the eyes, mouth, mucous membranes, because in that location is a burning result on them. The application of the cream should hold upwards twice a day. Typically, 1 fourth dimension of application inwards the forenoon in addition to the 2nd - in the evening. Azelaic acid command peel pigmentation past times influencing mainly on melatonin synthesis.
Azelaic Acid Side Effects.
Adverse effects that are really mutual with many of the patients applied the external cosmetic products, azelaic acid is burning, itching, redness (urticaria).
In the formulation, the next excipients with azelaic acid: conservant- benzoic acid; in
creams ever dispersant in addition to dispersed phase. Carriers (solvents) of the polar type are:
purified water, glycerol, propylene glycol; Fat-based (non-polar solvents used): triglycerides,
fatty alcohols, a mixture of mono- in addition to diglycerides. And the weakly polar base, such as
polyoxyethylene ester.
In creams must comprise an emulsifier, which must hold upwards adapted inwards relation to Hidrofilno lipophilic treatment, which is determined past times the formula. The cream, which describes a composition is of the type of H2O inwards oil, the fossil oil is predominantly equally a footing for the dissolution of the active ingredients
Certain gels, which are non-abrasive effects on the marketplace azelaic acid is combined - with
salicylic acid 40%, mandelic acid, lactic acid. Used for the role of exfoliation of the torso of acne, acne in addition to other mutual types of inflammation affecting the peel diseases of
inflammatory nature.
Ordinary.
Azelaic acid included inwards the cosmetic recess shape of 10 % inwards xxx ml is a really effective add-on of every type of peel in addition to has antioxidant activity. The high-purity of azelaic acid is actually inwards a lightweight cream-gel system. Gotter does non usage them direct inwards broken skin. And must hold upwards using peel protection cream during the day.
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